Demodex Mites and Rosacea: Treatment Methods and Causes

Demodex mites in rosacea – it is confirmed by scientific info [5] that Demodex mites play an vital function in rosacea! Anybody with rosacea is aware of how irritating the situation is and the way few good therapy choices there are to maintain a remission. I’ve lengthy been treating my rosacea sufferers by combining medicines and skincare suggestions to assist heal rosacea inclined pores and skin and stop reoccurance by ‘masking all of the bases’ we all know play a task in rosacea – together with addressing mites.

Information is energy. This information lets you achieve management of rosacea and the infamous Demodex mites. We glance into therapy plans, one of the best routines and best merchandise, and the very nature of those pesky microscopic foes. You’ll be geared up to efficiently conquer facial mites and facial redness, pores and skin sensitivity, rosacea bumps, and obtain a radiant, wholesome complexion.

Scientists Have Been Rethinking the Significance of Mites in Rosacea!

Researchers proceed to unravel the advanced relationship between Demodex mites and rosacea.

We have lengthy recognized that:

• Each individual has Demodex mites of their pores and skin pores (sure, it is unsavory however true).
• Folks with rosacea have much more mites of their pores than regular.

As a result of everyone has Demodex mites, tiny creatures that reside naturally in our pores, medical doctors have ignored their presence. I haven’t. Over a few years, I would see mite stuffed pores below the microscope as an incidental discovering on pores and skin biopsies. I would famous that it typically correlated with run-away rosacea [6] together with pustules, crimson delicate pores and skin, and infrequently patches of pores and skin with small spikes of whitish scale protruding of facial pores that have been surrounded by redness (pityriasis folliculorum). Due to this, I’ve been treating Demodex mites for many years and located that my rosacea affected person’s pores and skin improves once I do!

I am thrilled that latest scientific research are giving us some fascinating info that helps my therapy strategies. 

Outcomes of increasingly more scientific papers are suggesting a major function for Demodex mites in driving rosacea of each facial pores and skin and the eyes. In actual fact, authors of a scientific evaluate paper [7] on rosacea and Demodex say this in regards to the function of Demodex in rosacea:

“Rosacea favors the proliferation of Demodex, and the over-proliferation of Demodex aggravates the signs of rosacea, thus forming a vicious circle.”

We glance deeper into the connection between mites and rosacea, together with causes, micro organism on mites, pores and skin issues, eyelash mites, mites on scalps, and different information beneath. However first let’s have a look at your Demodex mites and rosacea therapy choices:

What’s the Remedy for Demodex Mites and Rosacea

The care pointers for rosacea are consistently evolving. Within the 35+ years that I’ve practiced dermatology, the usual rosacea therapies have relied on oral and topical antibiotics. We don’t know fully why antibiotics helped rosacea. It could be by focusing on micro organism which might be current within the pores and skin or on the mites. Some antibiotics even have anti–inflammatory results separate from their antibacterial properties.

A lot of my sufferers are unwilling to make use of antibiotics long run so I’ve labored onerous to search out various remedies – together with addressing mites.

Dr. Bailey’s Pores and skin Care Technique

Science and A long time of Expertise Backed Elements and Technique

I developed my suggestions primarily based on what labored for my many rosacea sufferers and observations I made below the microscope on pores and skin biopsies. When I’ve a suspicion that mites are taking part in a task in a affected person’s rosacea signs, my technique consists of two key parts:

1. I embrace particular topical anti-mite prescription medicines (extra on this beneath)
2. As a result of mite re-infestation is the norm, I additionally advocate particular skincare steps and merchandise to discourage mites from coming again and thriving in abundance

The strategy works synergistically to get rid of and management Demodex mites, soothe irritation, and reveal a more healthy, calmer complexion.

4-Step Pores and skin Care Routine to Deal with Rosacea and Demodex Mites

Take management of rosacea and pesky Demodex mites with my Full Pores and skin Care Routine™ which consists of 4 important steps: Cleanse, Appropriate, Hydrate, Defend. As a dermatologist, I’ve seen its transformative energy firsthand. 

This routine tackles each rosacea and its mitey culprits, leaving you with a calmer, clearer complexion, free from redness, bumps, and breakouts. Your pores and skin will really feel soothed, with minimized pores and replicate a wholesome, radiant glow.

Bear in mind, consistency and skilled steerage are key for optimum outcomes!

The core of this routine is my Rosacea Remedy Equipment, and I’ve strategically added the Benzoyl Peroxide Cream and Omega Enriched Face Booster Oil to deal with Demodex mites with rosacea.

Let’s have a look at easy methods to use and layer these merchandise with the 4-step routine:

1. Cleanse

Floor cleaning can wash off Demodex mites outdoors the pores, together with pores and skin yeast. Facial pores and skin cleaning twice every day is vital for controlling Demodex mites. [12]

• Cleanse pores and skin with a 2% pyrithione zinc fortified cleaning soap (Calming Zinc) twice a day.
• This helps steadiness a pores and skin yeast germ known as Pityrosporum/Malassezia that additionally grows abundantly on rosacea-prone complexions.
• Delicate complexions do greatest alternating the two% Calming Zinc cleaning soap within the morning with pH balanced soapless Extraordinarily Light Foaming Facial Cleanser at evening.
• For non-allergic sufferers, I could select a prescription pores and skin cleanser with sulfa medicine if essential.

All the time rinse pores and skin rather well after cleaning as a result of retained cleanser will irritate pores and skin and proceed to drag pores and skin lipids out of pores and skin layers.

2. Appropriate

Efficiently treating facial mites and rosacea is not nearly cleaning away mites, micro organism, yeast and impurities comparable to useless pores and skin cells and extra sebum. Science has unlocked a treasure trove of focused corrective elements and potent remedies, ready to be mixed and layered into a personalised routine that unleashes their true potential.

• To appropriate out of steadiness pores and skin irritation, I all the time have my sufferers apply Inexperienced Tea Antioxidant Pores and skin Remedy first, proper after the cleaning and towel drying the pores and skin.
• This soothing cream comprises pharmaceutically pure and secure inexperienced tea polyphenols equal to what’s extracted in 500 cups of inexperienced tea.
• This in style topical product masses the pores and skin’s antioxidant reserve to assist struggle pores and skin stressors.
• For shiny pustular rosacea and irritation, strive making use of Benzoyl Peroxide Cream twice a day to lively areas. It may be irritating however can typically even be very uniquely applicable and might probably deal with mites.
• If topical medicines are getting used, comparable to metronidazolel, Finacea or ivermectin/Soolantra (which particularly kills Demodex mites), I’ve my sufferers layer these on prime of the Inexperienced Tea cream.

Professional-tip: I prescribe the very economical permethrin cream to my rosacea sufferers and have them apply it to their face and neck twice a day for per week after which twice a day for 1 to 2 days each month to regulate Demodex mites. This can be a distinctive therapy that I developed so ask your dermatologist if this is perhaps best for you.

3. Hydrate

The hydrate step is vital as a result of barrier integrity is weak in rosacea-prone pores and skin. Your pores and skin will not heal if it’s not correctly hydrated.

• Hydrate your pores and skin with Day by day Moisturizing Face Cream utilized over the merchandise you used above.
• Enrich the Day by day Moisturizing Face Cream with a couple of drops of the Omega Enriched Face Booster Oil to profit from the important oils (comparable to sea buckthorn) and castor seed oil.
• At evening, it’s possible you’ll even wish to change the Moisturizing Cream with the Omega Oil. on to your face.

4. Defend

The shield step is actually vital for controlling rosacea as a result of UV publicity can set off rosacea flares. My best choice for every day solar safety for rosacea inclined complexions is a mineral zinc oxide broad spectrum sunscreen.

• Apply the non-irritating Sheer Energy Bodily Matte Tinted SPF 50+ Sunscreen through the day – daily – to forestall UV triggering of rosacea.
• It’s evenly tinted with iron oxide to assist conceal complexion flaws. It blends in nicely to all complexion pores and skin tones, together with actually truthful pores and skin.
• Males find it irresistible too as a result of it does NOT seem like make-up.
• The matte texture helps conceal oily shine.
• The iron oxide helps filter seen and blue display screen mild recognized to trigger pores and skin injury.

It is that straightforward! This non-prescription dermatologist’s Full Pores and skin Care Routine covers the entire essential elements that trigger rosacea, set off rosacea, or are the implications of rosacea, full with focused merchandise that management Demodex mites. If essential, I mix these focused skincare merchandise with topical prescription medicines to deal with rosacea.

Comply with the 4-Step Routine with the Rosacea Remedy Equipment

I created my Rosacea Remedy Equipment to take the guesswork out of constructing a therapeutic skincare routine for these affected by rosacea. The above steps add within the  Benzoyl Peroxide Cream and Omega Enriched Face Booster Oil to successfully struggle demodex mites with rosacea.

If you have already got a pH balanced cleanser (utilized in step 1) and an SPF (utilized in step 4) that you simply love, my Facial Flaking and Redness Answer Equipment mix the important thing non-prescription merchandise I exploit to focus on driving elements behind rosacea irritation.

How the Routine Works

This rigorously curated number of appropriate merchandise works collectively to heal rosacea, enhance your pores and skin’s resilience in opposition to irritation and mite overgrowth, and in the end help sustained remission. For a temperamental situation like rosacea, this complete strategy delivers the very best outcomes.

This routine:

• Fights irritation with antioxidants from inexperienced tea
• Consists of elements which will struggle mites and micro organism comparable to benzoyl peroxide, castor seed oil and sea buckthorn
• Incorporates zinc pyrithione to struggle pores and skin yeast that we now have lengthy recognized contribute to facial redness from rosacea
• Helps the delicate pores and skin barrier to heal with a lipid replenishing facial moisturizer
• Prevents UV ray publicity that may set off rosacea utilizing a non-irritating zinc oxide sunscreen

Medical Therapies Utilized by Dermatologists to Deal with Demodex Mites in Rosacea

How I’ve Been Treating Facial Demodex Mites in Rosacea Sufferers

Right here, I record a few of the Demodex mites therapy choices I am going over with my rosacea sufferers. It is very important focus on these together with your treating doctor to see if they’re best for you.

• Oral ivermectin. The mites could come again simply, so repeated remedies over time could also be essential to regulate Demodex. Oral therapy will penetrate each pores and skin and the eyelash space.
• Topical ivermectin lotions, comparable to Soolantra can deal with demodex mites. This can’t be used within the eye space. It tends to be an costly drugs, sadly.
• Remedy with permethrin (an off-label strategy for Demodex) prescription cream nightly for per week. I’ve my sufferers repeat this as essential. This additionally can’t be used to deal with the attention space.
• Topical metronidazole could cut back pores and skin irritation. Oral metronidazole could have some efficacy in opposition to mites although I want to depend on topical medicines to deal with rosacea.
• IPL (intense pulsed mild) additionally helps cut back the mite inhabitants [4]. It additionally diminishes the blood vessel capillaries and, in my expertise, helps cut back pores and skin irritation in rosacea.
• Pure choices embrace tea tree oil, peppermint oil, salvia oil, bergoment oil, black seed oil and castor seed oil. Of those, I’ve used castor seed oil in my Omega Enriched Face Oil. All of the others are recognized pores and skin irritants – one thing we wish to keep away from in rosacea – and might trigger pores and skin allergy.
• Hygiene steps to discourage mite reinfection and overgrowth embrace conserving pores and skin clear, frequent washing of linens together with mattress linens, avoiding sharing make-up and facial sponges.
• Following my confirmed Full Pores and skin Care Routine for a profitable therapy. See the main points and steps within the 4-Step Pores and skin Care Routine part of this information.

My Rosacea Remedy Equipment is the core of a skincare routine that helps prescription care in order that your rosacea heals. To deal with Demodex mites, my 4-step skincare routine provides in Benzoyl Peroxide Cream and Omega Enriched Face Booster Oil. (In fact, focus on your skincare routine together with your prescribing physician in case you are receiving prescription medicines.)

What Kills Demodex Mites?

Does Benzoyl Peroxide Kill Demodex Mites?

Years in the past, I attended an American Academy of Dermatology lecture given by a doctor practising in Israel the place they use benzoyl peroxide for Demodex. Permethrin was not accessible there and topical ivermectin had but to be invented. This doctor mentioned she achieved good management of facial Demodex infestation and rosacea pustules with topical benzoyl peroxide.

Benzoyl peroxide is used within the veterinary medical literature to assist management Demodex pores and skin infestations in canine. As well as, the benzoyl peroxide-erythromycin topical drugs mixture has been discovered helpful for treating facial demodex infestation in people. [13]

Benzoyl peroxide will be irritating to delicate rosacea-prone pores and skin nonetheless. I exploit my alcohol-free Benzoyl Peroxide Cream for complexions affected by rosacea. Comply with the 4-step skincare routine on this information to include it into your routine.

Another choice is Foaming Benzoyl Peroxide Cleanser. This light pH balanced cleanser has a full 10% benzoyl peroxide. Delicate pores and skin rosacea-prone complexions could not tolerate benzoyl peroxide so care have to be taken.

Do Antibiotics Kill Demodex?

No, antibiotics usually are not antiparasitic medicines. However topical and oral antibiotics have been the mainstay of rosacea remedy for years. They could assist cut back mite numbers, sluggish the return of mites, goal the micro organism on the mites that play a task in rosacea and should exert anti-inflammatory results on rosacea infected pores and skin.

Is there a Pure Remedy for Demodex Mites?

Some important oils seem to kill Demodex mites however on the concentrations used, these oils can be irritating to rosacea. Tea tree, sage, and peppermint have been the simplest in a small examine [3], although all oils in the end killed Demodex together with sea buckthorn, which is a soothing oil that helps calm pores and skin irritation.

My Omega Enriched Face Booster Oil (utilized in step 3 of my skincare routine) incorporates sea buckthorn and castor seed oil, each of which have been studied in opposition to Demodex, with different botanical therapeutic oils comparable to borage, kakui nut, argan oil, pomegranate oil, cypress and others to sooth and help delicate pores and skin.

I feel there’s a function for every day botanical oil use to assist management the Demodex mite recolonization of rosacea-prone pores and skin. I personally apply my Omega Oil at bedtime on prime of my different nighttime therapy merchandise. My 4-step skincare routine guides you on easy methods to use this oil in your rosacea therapy.

Does Pyrithione Zinc Kill Demodex Mites?

Zinc pyrithione in my Calming Zinc Cleaning soap (utilized in step 1 of the routine) has been useful for controlling rosacea. Whether or not it helps decelerate mites, or their micro organism, or is simply engaged on Pityrosporum/Malassezia yeast, it’s not totally understood, however it’s efficient and I all the time advocate it. A Russian examine finished in 2012 confirmed that pyrithione zinc decreased each Malassezia pores and skin yeast and demodex mites in sufferers with seborrheic dermatitis. Seborrhea and rosacea typically overlap, as does this yeast and the mites.

Comply with the skincare routine above, which contains this Zinc Cleaning soap with different complimentary merchandise to assist struggle rosacea and Demodex mites.

The Relationship Between Facial Mites and Rosacea

Do Demodex Mites within the Pores Trigger Rosacea?

The pores in your pores and skin are dwelling to many microscopic inhabitants together with micro organism, yeast, and – sure – mites. The rosacea puzzle is taking kind and microscopic Demodex mites play an vital function within the pores and skin issues of rosacea! [1] Mammals, together with people, have Demodex on their pores and skin. Demodex mites primarily reside in our pores and oil glands.

Demodex mites:

• Favor the oiliest components of our face such because the “T-zone”.
• Eat useless pores and skin cells and sebum (pores and skin oil).
• Are shy! The mites not often enterprise out of the pores the place they reside, lay their eggs, and die.

Precisely how mites trigger rosacea is advanced and nonetheless being labored out. We all know that Demodex mites can weaken pores and skin barrier integrity. This results in extreme pores and skin sensitivity to traditional rosacea triggers comparable to harsh climate, skincare merchandise and even solar.

A few of the early indicators of rosacea, together with flushing, redness and ‘damaged capillaries’ [5], additionally happen when there are elevated numbers of mites within the pores. The crimson pores and skin bumps of rosacea, known as granulomas, occur when pores and skin immune cells gather round mite stuffed pores.

Research additionally counsel that the overgrowth of Demodex mites could ultimately alter the pores and skin’s immune steadiness and capillary perform in ways in which favor the mite’s personal survival and proliferation. [5] As if the mite-skin interplay isn’t sophisticated sufficient, further papers  means that it’s not simply the mites, it’s a protein on a micro organism [8] that the mites carry that causes a few of the irritation of rosacea – wow, you possibly can see how this matter is sophisticated – and the mite/micro organism/rosacea connection could also be one of many the reason why antibiotics have been one of many useful medicines used to deal with rosacea for a few years!

What Rosacea Pores and skin Issues are Linked to Demodex Mites?

1. Pores and skin barrier fragility (delicate pores and skin)
2. Flushing
3. Everlasting “damaged” facial capillaries
4. Sebaceous hyperplasia (enlargement of oil glands)
5. The crimson rash, bumps and pustules of rosacea

Folks with Rosacea Have Extra Mites in Their Pores

Whereas we have recognized that rosacea inclined complexions have a larger variety of mites within the pores, the precise relationship remained a thriller for years. The connection between Demodex mites and rosacea is turning into more and more clear. Demodex mites are able to set off an inflammatory cascade that results in the signs of rosacea. Scientific research in medical journals have additionally gathered proof on how micro organism dwelling on human Demodex mites could play a vital function in triggering a posh cascade of occasions that result in the pores and skin issues of rosacea flares.

Many scientific papers now hyperlink the pores and skin issues attribute of rosacea comparable to redness, bumps, extreme pores and skin sensitivity, flushing and elevated seen pores and skin capillaries with Demodex mites. This data paves the way in which for probably simpler and customized therapy choices sooner or later.

Please see my confirmed 4-step system on this information that mixes my Rosacea Remedy Equipment with the mite-fighting duo of Benzoyl Peroxide Cream and Omega Enriched Face Booster Oil to actively goal and get rid of Demodex mites and rosacea.

Micro organism on Demodex Mites Could Be the Explanation for Rosacea Pores and skin Issues

There are two micro organism which may be accountable, Bacillus oleronius and Staphylococcus epidermidis. Curiously, these microbes are delicate to the antibiotics that we dermatologists have used for years to deal with rosacea. It could have been the mite’s micro organism that we have been treating all alongside. Conclusions have not been reached but it surely’s fascinating, shocking, and just a bit creepy. I focus on my strategy to medical remedies within the above part.

Eyelash Mites: Folks with Rosacea Have Extra Demodex Mites in Their Eyelash Follicles

Having rosacea means that you’re extra more likely to have an elevated variety of mites [9] within the hair follicles of your eyelashes. Demodex mites in eyelash hair follicles can lead to blepharitis with redness, swelling and itching of the pores and skin alongside the lash line. Dandruff [10] of the lashline with buildup of scale and crusting has additionally been linked to the presence of Demodex. It’s potential to have these eyelash signs with or with out occular rosacea.

See the Medical Therapies I exploit to deal with Demodex mites in eyelashes.

Demodex Mites Can Trigger Pustules, Redness, and Scale on the Scalp

Demodex within the hair follicles of the scalp will be related to a few of the identical signs of rosacea, specifically redness and pustules. [11] That mentioned, this doesn’t imply that having rosacea in your face means that you’ve got rosacea in your scalp. It does imply that when you have loads of mites within the pores of your face and lash line, you may additionally have mites within the follicles of the scalp. The excellent news is that a few of the oral mite remedies (see my therapy strategy above) that assist management the mites driving your rosacea may additionally deal with mites alongside the lashline and within the hair follicles of your scalp.

The Information About Demodex Mites on Our Pores and skin and Eyelashes

Demodex mites reside within the pores on locations of the human physique the place there may be loads of oil (T-zone, chest, ear canal, and groin). Solely not often can they get by way of the liner of the pore and into the second layer of the pores and skin known as the dermis. After they do, they could trigger extreme irritation comparable to giant inflammatory pustules (pimples). It could be this entrance into the pores and skin that’s liable for a few of the worst inflammatory features of rosacea.

• Demodex mites reside for lower than 3 weeks and their eggs hatch in lower than 3 days.
• They need to be in a pore to outlive; they will’t reside outdoors the pore. They solely come out of the pore at evening to mate, touring at most ½ inch away from their dwelling for relationship functions! When finished, they scramble again down into their pore to put their eggs.
• Human infants are born with no mites, after which their pores slowly change into inhabited by them. Each race in all components of the world has Demodex mites – sorry to interrupt the information however none of us are spared!
• As we age, we change into extra more likely to have loads of mites in our pores. In actual fact, 100% of the aged have Demodex mites of their pores. It could be the standard of sebum (oil) not the amount that makes the pores hospitable for the mites for the reason that aged outpace teenagers in pores and skin mite density. There may additionally be some ingredient of immune underperformance on the a part of our pores and skin that enables the mites to thrive.
• There are two kinds of mites; they reside in several components of the pores and trigger completely different manifestations of rosacea.
• Demodex folliculorum lives in the primary portion of the pore and it is extra more likely to trigger scaling redness and delicate pores and skin.
• Demodex brevis lives deeper within the sebaceous glands (which comes off the pore) and is extra more likely to trigger the papulopustular eruption (rosacea pimples), the symmetrical rashes, and different pores and skin issues arising on the background of a pre-existing rosacea.
• The B. oleronius micro organism are discovered on the Demodex mites that colonize human pores and skin. It could truly be a protein on the B. oleronius bacterium that’s able to resulting in a few of the vital inflammatory cascade seen in rosacea together with ocular rosacea.
• Demodex can act as a vector for micro organism and the mites presence is related to co-infecting pores and skin micro organism and fungi. This co-infection could play a task in pores and skin issues comparable to chalazions, styes, pustules and crimson bumps amongst others.

The Backside Line with Mites and Rosacea

The underside line is that we could also be getting nearer to understanding Demodex mites and rosacea. I anticipate to see extra focused remedies being developed, and possibly even a remedy, because the analysis continues. For now, the brand new give attention to mites is gross, however fascinating. As a ultimate observe the authors of a examine [1] state:

The pathogenic function of Demodex mites, in addition to B. oleronius and S. epidermidis, within the induction and persistence of rosacea stays an unresolved challenge.

So, till then, we sufferers and physicians need to be inventive at attempting to reign within the irritation and pores and skin issues of rosacea.

Take Management of Rosacea and Demodex Mites

As a dermatologist, I’ve seen the frustration of persistent rosacea and Demodex flare-ups. The 4-step skincare routine outlined on this information combines the facility of the hand-selected merchandise in my Rosacea Remedy Equipment with the scientifically-backed advantages of Omega Enriched Face Oil and Benzoyl Peroxide Cream.

This constant strategy with a focused assault on each rosacea and Demodex mites helped me heal a lot of my persistence with lasting outcomes.

By constructing your routine with these potent allies, layering them for max affect, you’ll unlock the door to a radiant, even-toned complexion. Your pores and skin can  be free from redness, irritation, and pesky bumps and resilient in opposition to on a regular basis stressors, each environmental and microscopic.

Discover Additional

If you want a extra in-depth dialogue on rosacea skincare, try the next guides:

Obtain a Free Copy of My Rosacea eBook

Be taught all about what it’s and what you are able to do about it.

Different articles you possibly can be taught extra from:

 You can even go to my Pores and skin Care Recommendation web page and scroll right down to the Glossary the place you will see a list of my hottest rosacea articles.

In regards to the Creator

Dr. Cynthia Bailey M.D. is a Board Licensed dermatologist practising dermatology since 1987. She has finished nicely over 200,000 pores and skin exams throughout her profession and authors the longest operating doctor written pores and skin well being weblog on the planet.

References

1. The potential function of Demodex folliculorum mites and micro organism within the induction of rosacea.  Stanisław Jarmuda, Niamh O’Reilly, Ryszard Żaba, Oliwia Jakubowicz, Andrzej Szkaradkiewicz and Kevin Kavanagh Journal of Medical Microbiology Papers in Press . Revealed August 29, 2012
2. Remedy of demodicosis in canine: 2011 medical apply pointers. Ralf S Mueller, Emmanuel Bensignor, Lluís Ferrer, Birgit Holm, Stephen Lemarie, Manon Paradis, Michael A Shipstone. Nationwide Middle for Biotechnology Info, February 13, 2012 
3. Impact of important oils on the survival price of Demodex spp. Maciej Okay Oseka; Aleksandra Sedzikowska, iOVS Avro Journal, April 2014
4. Dispelling the Thriller of Demodex, The Dermatologist, January 2007
5. Forton FMN. The Pathogenic Position of Demodex Mites in Rosacea: A Potential Therapeutic Goal Already in Erythematotelangiectatic Rosacea? Dermatol Ther (Heidelb). 2020 Dec;10(6):1229-1253. doi: 10.1007/s13555-020-00458-9. Epub 2020 Oct 23. PMID: 33095403; PMCID: PMC7649190.
6. Forton F, Germaux MA, Brasseur T, De Liever A, Laporte M, Mathys C, Sass U, Stene JJ, Thibaut S, Tytgat M, Seys B. Demodicosis and rosacea: epidemiology and significance in every day dermatologic apply. J Am Acad Dermatol. 2005 Jan;52(1):74-87. doi: 10.1016/j.jaad.2004.05.034. PMID: 15627084, PubMed
7. Fen Wei, Li Li, Yi Kong, Xiaofeng Yan, Kevin J. Varghese, Music Zhang, Jian Jiang, Bao Chai, Hongxiang Chen; Proof for the Scientific Affiliation between Demodex and Rosacea: A Evaluate. Dermatology 2023; Karger
8. Two AM, Wu W, Gallo RL, Hata TR. Rosacea: half I. Introduction, categorization, histology, pathogenesis, and danger elements. J Am Acad Dermatol. 2015 Could;72(5):749-58; quiz 759-60. doi: 10.1016/j.jaad.2014.08.028. PMID: 25890455, PubMed
9. Gonzalez-Hinojosa D, Jaime-Villalonga A, Aguilar-Montes G, Lammoglia-Ordiales L. Demodex and rosacea: Is there a relationship? Indian J Ophthalmol. 2018 Jan;66(1):36-38. doi: 10.4103/ijo.IJO_514_17. PMID: 29283119; PMCID: PMC5778578 PubMed
10. Cheng, A.M., Galor, A., Banoub, R. et al. The affect of ocular demodicosis on the eyes. Eye 37, 3061–3062 (2023).
11. Helou W, Avitan-Hersh E, Bergman R. Demodex Folliculitis of the Scalp: Clinicopathological Research of an Unusual Entity. Am J Dermatopathol. 2016 Sep;38(9):658-63. doi: 10.1097/DAD.0000000000000512. PMID: 26959693. PubMed 
12. Chudzicka-Strugała I, Gołębiewska I, Brudecki G, Elamin W, Zwoździak B. Demodicosis in Totally different Age Teams and Various Remedy Choices-A Evaluate. J Clin Med. 2023 Feb 19;12(4):1649. doi: 10.3390/jcm12041649. PMID: 36836184; PMCID: PMC9961532. MDPI
13. Oztürkcan S, Ermertcan AT, Sahin MT, Afşar FS. Effectivity of benzoyl peroxide-erythromycin gel as compared with metronidazole gel within the therapy of pimples rosacea. J Dermatol. 2004 Aug;31(8):610-7. doi: 10.1111/j.1346-8138.2004.tb00566.x. PMID: 15492433; PubMed 

Further Research Referenced

Zhao YE, Wu LP et. al., Retrospective evaluation of the affiliation between Demodex infestation and rosacea,  Arch Dermatol. 2010 Aug;146(8):896-902

Elston DM, Demodex mites: information and controversies, Clin Dermatol. 2010 Sept-Oct;28(5):502-4

Li J, O’Reilly N, et. al., Correlation between ocular Demodex infestation and serum immunoreactivity to Bacillus proteins in sufferers with facial rosacea, Ophthalmology. 2010 Could;117(5):870-877

Gao YY, Di Pascuale MA, In vitro and in vivo killing of ocular Demodex by tea tree oil, Br J Ophthalmol 2005 Nov;89(11);1468-73

Forton FM. Papulopustular rosacea, pores and skin immunity and Demodex: pityriasis folliculorum as a lacking hyperlink. J Eur Acad Dermatol Venereol. 2012 Jan;26(1):19-28. doi: 10.1111/j.1468-3083.2011.04310.x. Epub 2011 Oct 24. PMID: 22017468.

Kim JS, Website positioning BH, Cha DR, Suh HS, Choi YS. Upkeep of Remission after Oral Metronidazole Add-on Remedy in Rosacea Remedy: A Retrospective, Comparative Research. Ann Dermatol. 2022 Dec;34(6):451-460. doi: 10.5021/advert.22.093. PMID: 36478427; PMCID: PMC9763916.

MOKRONOSOVA M.A., GLUSHAKOVA A.M., GOLYSHEVA E.V., ZHELTIKOVA T.M. Demodex mites and Malassezia yeast at sufferers with seborrheic dermatitis // Vestnik dermatologii i venerologii. – 2012. – Vol. 88. – N. 3. – P. 92-98. doi: 10.25208/vdv693